![]() ![]() ![]() The results denote that leiomyomas do not affect the different races equally African American (AA) women have leiomyoma-related symptoms more frequently than caucasian women (85% vs 63% P =. Weiss et al published (2009) a multiethnic, multicenter, community-based longitudinal cohort study of 3302 women between the ages 42 and 52 in which the authors surveyed the overall perceived health before and after hysterectomy in addition to the presenting symptoms. Uterine Leiomyomas are More Common in African Americans Uterine leiomyomas are the most cited indication for more than 600 000 hysterectomies performed in the United States annually, and this major surgery is associated with morbidity and mortality as well as a huge economic impact on health care delivery systems that is estimated to be approximately $2.2 billion/year. ![]() 5 These clinical complications negatively impact women’s health. Uterine leiomyomas have also been associated with numerous other medical disorders, such as infertility, recurrent abortion, and preterm labor. Although they are benign, they commonly result in severe symptoms, such as heavy, irregular, and prolonged menstrual bleeding as well as anemia. ![]() 4 Leiomyomas may enlarge to cause significant distortion of the uterine surface or cavity. 2, 3 A thin pseudocapsule that is composed of areolar tissue and compressed muscle fibers usually surrounds the tumors. 1, 2 They are monoclonal tumors of the smooth muscle cells of the myometrium and consist of large amounts of extracellular matrix that contains collagen, fibronectin, and proteoglycan. Uterine leiomyomas are the most common benign pelvic tumors in women. In the present review, we will discuss these promising medical treatments in further detail. In recent years, a few clinical trials have evaluated the efficacy of orally administered medications for the management of leiomyoma-related symptoms. Surgery has traditionally been the gold standard for the treatment of uterine leiomyomas and has typically consisted of either hysterectomy or myomectomy. Uterine myomas cause several reproductive problems such as heavy or abnormal uterine bleeding, pelvic pressure, infertility, and several obstetrical complications including miscarriage and preterm labor. These common tumors cause significant morbidity for women and they are considered to be the most common indication for hysterectomy in the world they are also associated with a substantial economic impact on health care systems that amounts to approximately $2.2 billion/year in the United States alone. Pathologically, uterine leiomyomas are benign tumors that arise in any part of the uterus under the influence of local growth factors and sex hormones, such as estrogen and progesterone. The prevalence of leiomyomas is at least 3 to 4 times higher among African American women than in white women. Uterine leiomyomas (also called myomata or fibroids) are the most common gynecologic tumors in the United States. ![]()
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